(a) Domain organization of ATX. (b) Ribbon diagram of the ATX structure in the free form. (c) Surface representation of the ATX structure in the free form. Somatomedin B-like domain 1 (SMB1), orange; SMB2, brown; core subdomain, cyan; insertion (Ins) subdomain, pale cyan; nuclease-like domain (NLD), magenta; L1, beige; L2, yellow-green; EF hand–like motif, pink. N-glycans and sulfate ion are shown as yellow and orange sticks, respectively. Zn2+, Ca2+, Na+ and K+ ions are shown as gray, green, purple and blue spheres, respectively. All 15 disulfide linkages are shown as sticks.
Higher levels of the enzyme, autotaxin, significantly predict memory impairment and type 2 diabetes. The research emphasizes the link between physical and mental health...
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