Highlights • Arid1a loss results in improved regeneration after diverse liver injuries • Arid1a overexpression impairs liver proliferation and regeneration • Arid1a loss also improves tissue repair after ear hole punch • Arid1a loss remodels chromatin, altering transcriptional access by C/EBPα and E2F4
The liver is unique among human solid organs in its robust regenerative capability. This research gives us ideas about new ways to treat liver damage or chronic liver disease,” said Dr. Hao Zhu, an Assistant Professor at CRI. Tails in lizards and arms in starfish show an astounding ability to regrow, but mammals have partially lost the capacity to extensively regenerate body parts, Dr. Zhu said. The liver is unique among human solid organs in its robust regenerative capability...
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