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    Longevity-linked APOE2 gene variant tagged posts

    Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging

    May 19, 2026, Categories  Health/Medical, Biology/Biotechnology

    Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging
    This image is an artistic representation of how APOE2 promotes resilience to cellular senescence maintaining the integrity of DNA and the nuclear envelope. We show a neuron protected by APOE2 represented as orange dots across the cell, with a blue mesh representing the resistance to senescence. We highlight in golden the integrity of the nucleus and the protected genome. Credit: Ella Maru for the Buck Institute

    People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer’s disease, but scientists have struggled to explain why...

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