longevity tagged posts

Researchers discover an unexpected link between DNA winding and metabolism in the gut to ameliorate aging. Our genetic material is stored in our cells in a specific way to make the meter-long DNA molecule fit into the tiny cell nucleus of each body cell...

Data from over 9,000 people reveal a distinct gut microbiome signature that is associated with healthy aging and survival in the latest decades of life. The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism.

The research team analyzed gut microbiome, phenotypic and clinical data from over 9,000 people — between the ages of 18 and 101 years old — across three independent cohorts...

Figure 3U-shaped association between percentage of energy from carbohydrate and all-cause mortality in the ARIC and PURE cohort studies. The reference level is 46·4% energy from carbohydrate. ARIC results are adjusted for age, sex, education, waist-to-hip ratio, smoking, physical activity, diabetes, ARIC test centre, and energy intake. PURE results are are adjusted for age, sex, education, waist-to-hip ratio, smoking, physical activity, diabetes, urban or rural location, centre, geographical regions, and energy intake.13 The mean percentage of energy from carbohydrate in ARIC is 49%, and from PURE it is 61%. ARIC=Atherosclerosis Risk in Communities. PURE=Prospective Urban Rural Epidemiology.

Eating carbohydrates in moderation seems to be optimal for health and longevity, suggests new rese...