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    Loss of IRF4 in BAT causes decreased exercise capacity and a selective myopathy tagged posts

    New Light Shed on Relationship between Calorie-Burning Fat and Muscle function

    August 5, 2018, Categories  Biology/Biotechnology, Health/Medical

    Highlights • Loss of IRF4 in BAT causes decreased exercise capacity and a selective myopathy • IRF4 represses myogenic genes in BAT, including the myokine myostatin • Neutralizing serum myostatin rescues the ability of BATI4KO mice to exercise normally • Warming reduces IRF4 in BAT, causing myopathy that is reversed by removal of BAT

    Highlights
    • Loss of IRF4 in BAT causes decreased exercise capacity and a selective myopathy
    • IRF4 represses myogenic genes in BAT, including the myokine myostatin
    • Neutralizing serum myostatin rescues the ability of BATI4KO mice to exercise normally
    •Warming reduces IRF4 in BAT, causing myopathy that is reversed by removal of BAT

    Researchers open the door to potential new therapies for certain metabolic and muscular diseases. Now, endocrinologists at Beth Israel Deaconess Medical Center (BIDMC) have shown for the first time that brown adipose tissue (BAT), or brown fat, can exert control over skeletal muscle function. Alterations to the brown adipose tissue in mice resulted in a significant and consistent reduction in exercise performance...

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