lysosome tagged posts

University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash. The findings are an important step towards understanding and treating age-related diseases driven by leaky lysosomes.

“Lysosome damage is a hallmark of aging and many diseases, particularly neurodegenerative disorders such as Alzheimer’s,” said lead author Jay Xiaojun Tan, Ph.D., assistant professor of cell biology at Pitt’s School of Medicine and member of the Aging Institute, a partnership between Pitt and UPMC. “Our study identifies a series of steps that we believe is a universal mechanism for lysosomal repair, which we named the PITT pathway as a nod to the University of Pittsburgh.”

As the c...

New research from the University of Cincinnati shows early indications that light can be used as a treatment for certain diseases, including cancer.

Researchers from UC, the U222niversity of Illinois Urbana-Champaign and the University at Buffalo published the results of their study demonstrating light-activated proteins can help normalize dysfunction within cells in the journal Nature Communications July 25.

The research centers on the functions of mitochondria, organelles within a cell that act as...