Nucleus of a cell undergoing parthanatos. Credit: Yingfei Wang and I-Hsun Wu/Johns Hopkins Medicine
Common culprit may cause damage in stroke, brain injury, neurodegenerative disease like Alzheimer’s. Researchers at Johns Hopkins say they have pinpointed the protein at the end of that chain of events, one that delivers the fatal strike by carving up a cell’s DNA. The find, they say, potentially opens up a new avenue for the development of drugs to prevent, stop or weaken the process.
The new experiments, conducted in laboratory-grown cells, build on earlier work by research partners Ted Dawson, M.D., Ph.D., and Valina Dawson, Ph.D., professor of neurology...
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