1. Highlights • Quinolone antibiotics fail to kill bacterial populations at high density • Exhaustion of OXPHOS substrates drives bacterial persistence • Carbon and electron acceptor supplementation restores antibiotic activity • Metabolic priming of OXPHOS reverses tolerance in diverse bacterial species. 2.Sensitization to Cipro in Clinically Relevant Pathogens.Â
MIT researchers have discovered a way to make bacteria more vulnerable to quinolones, which include ciprofloxacin and are often used to treat infections such as E coli and Staphylococcus aureus. The new strategy overcomes a key limitation of these drugs, which is that they often fail against infections that feature a very high density of bacteria...
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