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    Gut-on-Chip Good Predictor of Drug Side-Effects

    August 22, 2017, Categories  Health/Medical, Biology/Biotechnology

    Overview of modeling intestinal tubules in the OrganoPlate platform with 40 microfluidic channel networks and 384-well plate format device; Bottom right: 3D artist impression of the center of a chip comprising a tubule, an extra cellular matrix gel and a perfusion lane; two phaseguides (white bars) are present that define the three distinct lanes in the central channel. The tubule has a lumen at its apical side that is perfused.

    Overview of modeling intestinal tubules in the OrganoPlate platform with 40 microfluidic channel networks and 384-well plate format device.
    Bottom right: 3D artist impression of the center of a chip comprising a tubule, an extra cellular matrix gel and a perfusion lane; two phaseguides (white bars) are present that define the three distinct lanes in the central channel. The tubule has a lumen at its apical side that is perfused.

    Research conducted at Leiden has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body...

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