In the conventional electron micrograph at left, it is difficult to distinguish form and function of two hippocampal astrocytes in a mouse brain. The multicolor micrograph at right marks the two astrocytes using different color lanthanides and more clearly shows where they contact and nurture the same synapse (dark railroad lines). Credit: Image courtesy of Stephen Adams, NCMIR, UC San Diego
Electron microscopy (EM), which uses particle beams of accelerated electrons to interrogate specimens, has long been a leading technology for revealing the shape and structure of the tiniest objects, from the cells which make up the bodies organs and microbes to individual building blocks or molecules which comprise cells, in often dramatic 3D detail...
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