Highlights
d Loss of one Mcl-1 allele substantially delays
lymphomagenesis
d MCL-1 antagonizes BIM in lymphoma development
d Loss of p53 reduces requirement for MCL-1 during
lymphomagenesis
A protein that is key to the development of blood cancers caused by a common genetic error has been identified by researchers. The discovery is a missing piece in the puzzle of understanding how high levels of a protein called MYC drive cancer development, and may to lead to future strategies for early treatment or possibly even prevention of these cancers.
70% of human cancers have abnormally high levels of MYC, which forces cells into unusually rapid growth...
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