ELV-N32 and ELV-N34 diminish NVU disruption and reduce brain infarction after ischemic stroke.
A new class of molecules in the brain that synchronize cell-to-cell communication and neuroinflammation/ immune activity in response to injury or diseases has been found. Elovanoids (ELVs) are bioactive chemical messengers made from omega-3 very long chain polyunsaturated fatty acids (VLC-PUFAs,n-3). They are released on demand when cells are damaged or stressed.
“Although we knew about messengers from omega-3 fatty acids such as neuroprotectin D1 (22 carbons) before, the novelty of the present discovery is that elovanoids are made of 32 to 34 carbon atoms in length,” notes Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans...
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