Naltrexone tagged posts

According to some estimates, chronic pain affects up to 40% of Americans, and treating it frustrates both clinicians and patients — a frustration that’s often compounded by a hesitation to prescribe opioids for pain.

A new study from the University of Michigan School of Dentistry confirms that a low dose of a drug called naltrexone is a good option for patients with orofacial and chronic pain, without the risk of addiction, said first author Elizabeth Hatfield, a clinical lecturer in the Department of Oral and Maxillofacial Surgery and Hospital Dentistry.

Naltrexone is a semisynthetic opioid first developed in 1963 as an oral alternative to naloxone, the nasal spray used to reverse opioid drug overdoses. When prescribed at doses of 50 to 100 milligrams, naltrexone
blocks the effe...

The efficacy of ( )-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity, 2017; DOI: 10.1016/j.bbi.2017.08.021

Researchers from the University of Adelaide have found a new link between the brain’s immune system and the desire to drink alcohol in the evening. In laboratory studies using mice, researchers have been able to switch off the impulse to drink alcohol by giving mice a drug that blocks a specific response from the immune system in the brain. Now published in the journal Brain, Behavior and Immunity, this research is one of the first of its kind to show a link between the brain’s immunity and the motivation to drink alcohol at night.

“Alcohol is the world’s most commonly consumed drug, and there is a greater need than ever...