Top view of the sieve, zooming in on the inverted pyramids. Credit: University of Twente
To study brain cell’s operation and test the effect of medication on individual cells, the conventional Petri dish with flat electrodes is not sufficient. For truly realistic studies, cells have to flourish within 3D surroundings. Bart Schurink, researcher at University of Twente’s MESA+ Institute for Nanotechnology, has developed a sieve with 900 openings, each of which has the shape of an inverted pyramid. On top of this array of pyramids, a micro-reactor takes care of cell growth.
A brain-on-a-chip demands more than a series of electrodes in 2D, on which brain cells can be cultured...
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