Neuronal Transport tagged posts

Highlights •FAD mutations impair endocytosis and transcytosis of APP and lipoproteins •Reduced lipoprotein endocytosis and transcytosis are rescued by β-secretase inhibition

Researchers have confirmed that mutation-caused dysfunction in a process cells use to transport molecules within the cell plays a previously suspected but underappreciated role in promoting the heritable form of Alzheimer’s disease (AD), but also one that might be remedied with existing therapeutic enzyme inhibitors. “Our results further illuminate the complex processes involved in the degradation and decline of neurons, which is, of course, the essential characteristic and cause of AD,” said Prof. Larry Goldstein, PhD.

Alzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss an...