neuroscience tagged posts

Researchers have a better understanding of the nocebo effect and the neuroscience behind it all. Opposite of the better-known placebo effect, where positive expectations trigger genuine pain relief, the nocebo effect is the experience from negative expectations, created by prior experience, verbal suggestion, or social observation, which can drive anxiety and make pain worse.

A new study published in Nature Communications, by researchers at the University of Toronto Mississauga and McGill University, identified a brain pathway through which negative expectations can amplify pain. The findings, generated independently by the two labs without prior coordination, converged on the neurochemical cholecystokinin (CCK), which has previously been linked to nocebo pain responses in humans.

As shown in this functional MRI image, the amygdala, a part of the brain involved in processing emotions, is more active in people who are blaming others for their negative actions. Credit: Lawrence Ngo

Judgment hinges on whether action was intentional or unintentional. We constantly read others’ intentions in what they do, especially political candidates. The Duke study is “the first to use neuroscience research tools to try to explain why people are biased toward treating negative actions as intentional but positive actions as unintentional,” said Lawrence Ngo.

Take this scenario commonly used in the field of experimental philosophy: The CEO knew the plan would harm the environment, but he did not care at all about the effect the plan would have on the environment...