NSAID tagged posts

Fighting colorectal cancer at UTHealth are Lenard Lichtenberger, Ph.D., (right) and Dexing Fang, Ph.D. Credit: Rob Cahill, UTHealth

When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced its side effects. Findings of the preclinical study of phosphatidylcholine, also called lecithin, appear in the journal Oncology Letters. “The results support the potential use of NSAIDs associated with phosphatidylcholine for the prevention and treatment of colorectal cancer,” said Lenard Lichtenberger, Ph.D., the study’s lead investigator and a professor of integrative biology and pharmacology at McGovern Medical School at UTHealth.

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Cheap Diclofenac has anti-cancer properties. Like other drugs examined by the ReDO project, diclofenac is cheap and readily accessible — and as it’s already present in many medicine cabinets, it has been carefully tested. The Repurposing Drugs in Oncology (ReDO) project, an international collaboration between the Anticancer Fund, Belgium, and US based GlobalCures, finds that existing and widely-used non-cancer drugs may represent a relatively untapped source of novel therapies for cancer.

Diclofenac is a well-known and widely used non-steroidal anti-inflammatory drug (NSAID) used to treat pain in conditions such as rheumatoid arthritis, as well as migraine, fever, acute gout and post-operative pain.

NSAIDs have shown promise in cancer prevention, but there is now emerging evidence that su...