NSF ATPase activity tagged posts

Revealing Roles of Dementia Proteins in Normal Memory

This study maps tau interactomes in mouse brain and neurons using proximity labelling. Direct interaction of tau with the vesicle and receptor trafficking factor NSF inhibits NSF ATPase activity and controls synaptic glutamate receptors underlying associative learning.

New research has revealed how the tau protein, a critical element in the formation of Alzheimer’s disease, is also involved in normal learning processes in the healthy brain — potentially providing a focal point for future drug therapies.

In the study, published in The EMBO Journal, Flinders University researchers have provided new insights into the tau protein, whose role has long been enigmatic, finding it may help molecular processes of memory formation.

Employing a sensitive method named proximity labelling, th...

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