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    obesity tagged posts

    Palm Oil in your Valentine’s Chocolate? Beware

    February 14, 2018, Categories  Biology/Biotechnology, Health/Medical

    Metabolic inflammation and NFкB-mediated neuroinflammatory responses in the NAc contribute to the expression of anxiodepressive behavior and heightened food cravings caused by a diet high in saturated fat and sugar.

    Metabolic inflammation and NFкB-mediated neuroinflammatory responses in the NAc contribute to the expression of anxiodepressive behavior and heightened food cravings caused by a diet high in saturated fat and sugar.

    A diet rich in saturated fat and sugar not only leads to obesity, it creates inflammation in the nucleus accumbens, a part of the brain that controls mood and the feeling of reward. And this inflammation can lead to depressive, anxious and compulsive behaviour and disrupt metabolism, according to a new study by researchers at the University of Montreal Hospital Research Centre (CRCHUM). Published in the journal Molecular Metabolism, the study on mice provides new evidence confirming the harmful effect of saturated fat on health.

    “The depressive, anxious and compulsive behaviou...

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    Learning and Staying in Shape key to Longer Lifespan, study finds

    October 14, 2017, Categories  Biology/Biotechnology, Health/Medical

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group. c Effects on mortality were studied in both age groups for both sexes. APOE has the strongest effect on females aged 75+, CHRNA3/5 acts on males aged 40−75 and all other genes display more ambiguous trends

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group...

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    Brain ‘Switch’ tells Body to Burn Fat After a Meal

    August 2, 2017, Categories  Biology/Biotechnology, Health/Medical

    Highlights •Diurnal changes in hypothalamic TCPTP coordinate feeding with energy expenditure •Feeding represses hypothalamic TCPTP to increase energy expenditure •TCPTP inhibits insulin signaling in AgRP neurons to repress energy expenditure •Insulin signaling in AgRP neurons increases the browning of white fat

    Highlights
    •Diurnal changes in hypothalamic TCPTP coordinate feeding with energy expenditure
    •Feeding represses hypothalamic TCPTP to increase energy expenditure
    •TCPTP inhibits insulin signaling in AgRP neurons to repress energy expenditure
    •Insulin signaling in AgRP neurons increases the browning of white fat

    Scientists at Monash University’s Biomedicine Discovery Institute have found a mechanism by which the brain coordinates feeding with energy expenditure, solving a puzzle that has previously eluded researchers and offering a potential novel target for the treatment of obesity. Obesity – a major risk factor for many diseases including cardiovascular disease, Type 2 diabetes, liver disease and several cancers – is at epidemic levels in Australia.

    Researchers from the Metabolic D...

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    Altering Gut Bacteria Pathways may Stimulate Fat Tissue to Prevent Obesity

    July 3, 2017, Categories  Biology/Biotechnology, Health/Medical

    Highlights •Plasma TMAO levels are elevated in type 2 diabetic patients •Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity •Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging •Inhibition of Fmo3 promotes resistance to obesity

    Highlights
    •Plasma TMAO levels are elevated in type 2 diabetic patients
    •Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
    •Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
    •Inhibition of Fmo3 promotes resistance to obesity

    Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

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