Oct4-nucleosome complex tagged posts

Computer Simulations Visualize how DNA converts Cells into Stem Cells

The pioneer transcription factor Oct4 (blue) binds to the nucleosome (a complex of proteins (green) and the DNA (orange) wrapped around these proteins). Credit: Jan Huertas and Vlad Cojocaru, ©MPI Münster, ©Hubrecht Institute.

Researchers of the Hubrecht Institute (KNAW — The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells. Their findings are published in the Biophysical Journal.

Signalling in the cell to start or stop reading DNA happens through proteins called transcription factors. Identity changes happen naturally during development as cells transition from an undesignated cell to a specific cell type...

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