Highlights •URI/OGT/PP1γ forms a functional heterotrimeric complex in cancer cells •Glucose depletion phosphorylates URI at Ser-371, releasing PP1γ to inhibit OGT •OGT inhibition reduces c-MYC, promoting cancer cell survival upon metabolic stress •URI (S371A) increases O-GlcNAcylation, c-MYC levels, and hepatocarcinogenesis
New research provides important clues that might help understand the resistance to drugs that ‘starve’ tumors, and also how cancer cells manage to survive in the center of the tumor mass, where barely any blood vessels can reach...
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