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Tiny Scorpion-derived Proteins deliver Arthritis Drugs to Joints in preclinical study

An Israeli death scorpion
More than a decade ago, Olson discovered a mini-protein found in the deathstalker scorpion that can bind to cancer cells but not healthy ones.Getty Images

Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.

“For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself,” said the project’s senior scientist Dr...

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