organ-on-a-chip tagged posts

Organ-on-a-chip technology replicates decades of human aging in just four days

An array of microfluidic chips with circuit-like patterns on a metal wafer, illuminated in blue, pink, and yellow light.
A prototype wafer shows various configurations that the Stahl lab tested before settling on their current design. UC Berkeley photo by Mathew Burciaga

Over one billion people worldwide are over 60, and the population is projected to more than double by 2050. But as more people live into their 60s, 70s, and 80s, health care systems across the globe may face new challenges as they attempt to manage associated increases in age-related disease.

Metabolic biologist Andreas Stahl and preeminent longevity researcher Irina Conboy argue that the graying of the global population underscores the need to understand aging as a biological process, and how it might be slowed or reversed...

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New Organ-on-a-Chip finds crucial interaction between Blood, Ovarian Cancer Tumors

Abhishek Jain and his team at Texas A&M are collaborating with researchers at MD Anderson Cancer Center and Rice University to develop and test their new microdevice, the ovarian tumor microenvironment-chip.
Texas A&M Engineering

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body. These organs-on-chips serve as a model of the state an actual cancer patient is in, thus allowing an opportunity to finding the correct treatment before administering it to the patient. At Texas A&M University, researchers are pushing these devices to new levels that could change the way clinicians approach cancer treatment, particularly ovarian cancer.

The team has recently submitted ...

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‘Gut-on-a-Chip’ system shows Intestinal Barrier Disruption is the onset initiator of Gut Inflammation

Biomedical engineering assistant professor Hyun Jung Kim with the gut-on-a-chip. Cockrell School of Engineering, The University of Texas at Austin

Biomedical engineering assistant professor Hyun Jung Kim with the gut-on-a-chip. Cockrell School of Engineering, The University of Texas at Austin

Once the gut barrier has been damaged, probiotics can be harmful just like any other bacteria. The first study investigating the mechanism of how a disease develops using human organ-on-a-chip technology has been successfully completed by engineers at The University of Texas at Austin.

Researchers from the Cockrell School of Engineering were able to shed light on a part of the human body – the digestive system – where many questions remain unanswered. Using their “gut inflammation-on-a-chip” microphysiological system, the research team confirmed that intestinal barrier disruption is the onset initiator of gut inflammation.

The study also include...

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