Reconstituting epithelial microtissues with programmed size, shape, composition, spatial heterogeneity and embedding ECM Credit: http://www.nature.com/nmeth/journal/vaop/ncurrent/images/nmeth.3553-F3.jpg
A technique to build organoids of human tissues using a process that turns human cells into a biological equivalent of LEGO bricks has been developed. These mini-tissues in a dish can be used to study how particular structural features of tissue affect normal growth or go awry in cancer. They could be used for therapeutic drug screening and to help teach researchers how to grow whole human organs.
Called DNA Programmed Assembly of Cells (DPAC), thousands of custom-designed organoids, eg models of human mammary glands containing several hundred cells each, can be built in a matter of hours...
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