oxidative stress tagged posts

1. A schematic of the sampling device built by researchers to measure levels of toxic particulate matter present during rush hour inside of a typical car cabin
2. A dashboard view from a vehicle taking measurements of certain types of pollutants during rush hour in Atlanta

In-car air study of commuting cars finds dangers to human health. The first in-car measurements of exposure to pollutants that cause oxidative stress during rush hour commutes has turned up potentially alarming results. The levels of some forms of harmful particulate matter inside car cabins was found to be twice as high as previously believed. Most traffic pollution sensors are placed on the ground alongside the road and take continuous samples for a 24-hour period...

Illustration shows the delivery route of hydrogen sulfide to damaged cells based on two projects completed in the University of Oregon lab of Michael Pluth. Credit: Michael Pluth

Molecules with the potential to deliver healing power to stressed cells – such as those involved in heart attacks – have been created by University of Oregon researchers. The research – done at a cellular level in the lab and far from medical reality – involves the design of organic molecules that break down to release hydrogen sulfide when triggered by specific conditions such as increased oxidative stress. Oxidative stress damages cells and is tied especially to heart disease and cancer, as well as Alzheimer’s and Parkinson’s disease.

“We have discovered that small organic molecules can be engineered to release ...

Propionibacterium acnes. Credit: Matthias Mörgelin, Lund University

Rolf Lood from Lund University in Sweden has shown that the most common bacteria on human skin, Propionibacterium acnes secrete a protein which protects us from the reactive oxygen species thought to contribute to several skin diseases. The protein has an equally strong effect on dangerous oxygen species as known antioxidants eg vitamin C and E.

“The name originates from the fact that the bacterium was first discovered on a patient with severe acne. But whether it causes acne is uncertain – it may have been present merely because it is so common,” says Rolf Lood, Lund. He has discovered that the “acne bacterium” secretes a proteinm RoxP...

Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).

If you’re an older adult, a 30 min workout may not be as effective, even at the cellular level, as it was when you were younger. According to a new study, age may play a significant role in a cell’s ability to respond to that activity. In the study, a group of men 18 to 30 yo were tested against a group of older men 55 years and older...