•Intense light-mediated cardioprotection requires endothelial-specific PER2
•Intense light-elicited PER2 transcriptionally reprograms the endothelium
•Endothelial PER2 regulates respiration and barrier function during hypoxia
•Studies of humans reveal intense light activates PER2-dependent metabolism
The light boosts a critical gene that strengthens blood vessels. Researchers at the University of Colorado Anschutz Medical Campus have found that intense light amplifies a specific gene that bolsters blood vessels and offers protection against heart attacks.
“We already knew that intense light can protect against heart attacks, but now we have found the mechanism behind it,” said the study’s senior author Tobias Eckle, MD, PhD, professor of anesthesiology at the University...
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