The study provides insights into evolutionary distribution of different types of existing protein complexes. The table provides a valuable tool for biotechnology and the engineering of novel complexes.
Almost every biological process depends on proteins interacting and assembling into complexes in a specific way, and many diseases are associated with problems in complex assembly. The principles underpinning this organisation are not yet fully understood, but by defining the fundamental steps in the evolution of protein complexes, the new ‘periodic table’ presents a systematic, ordered view on protein assembly, providing a visual tool for understanding biological function.
“Evolution has given rise to a huge variety of protein complexes, and it can seem a bit chaotic,” explains Joe Marsh...
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