1. Hypoxia-induced HIF1α targets in melanocytes reveal a molecular profile associated with poor melanoma prognosis. Pigment Cell & Melanoma Research, 2017; DOI: 10.1111/pcmr.12579
2. Hypoxia-dependent regulation of HIF-1 activity.
Insights provide possible new targets for personalized treatments. Cancerous tumors are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells metastasize to find more nourishment. Searching for clues about how the body signals the lack of oxygen in melanoma skin cancer, NIH researchers focused on HIF1alpha (hypoxia inducible factor 1 alpha), a protein that acts as a sensor for oxygen and nutrients in many types of cancer...
Read More
Recent Comments