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Like venom coursing through the body: Researchers identify Mechanism driving COVID-19 Mortality

Students in white lab coats and safety gear stand around a microscope in Dr. Chilton's lab
In a photo taken prior to the pandemic, Dr. Chilton (second from left) and his lab team examine how genetic and epigenetic variations interact with human diets to drive inflammation and inflammatory disorders, as well as psychiatric and developmental disorders.Chris Richards/University of Arizona

An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation.

Researchers from the University of Arizona, in collaboration with Stony Brook University and Wake Forest University School of Medicine, analyzed blood samples from two COVID-19 patient cohorts and found that circulation of the enzyme – secreted p...

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