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Heart Signaling Map sheds light on the Molecular Culprits behind Cardiovascular disease

Heart signaling map sheds light on the molecular culprits behind cardiovascular disease

Map of protein signaling pathways that went off course in DCM hearts. Credit: Uros Kuzmanov

An enlarged heart is a hallmark of dilated cardiomyopathy (DCM) and, despite being the most common inherited disease of the heart muscle, doctors don’t really know why it occurs. But that could now change as a new University of Toronto study begins to shine light on the molecular causes behind DCM. The study reveals widespread differences in protein biochemistry between healthy and diseased hearts. This expands our understanding of heart physiology and opens the door for future research that could improve detection and treatment of DCM.

Affecting all ages, the disease begins usually in adolescence and strikes 1 in 5 Canadians, with huge healthcare, economic and social costs...

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