The GS-DProSw molecule in its inactive form (blue) can be activated by visible light (red) and “switched off” again by UV light. Credit: KIT
Photoswitchable agents might reduce side effects of chemotherapy. So far, photodynamic therapies have been dependent on oxygen in the tissue. But hardly any oxygen exists in malignant, rapidly growing tumors. A group of researchers of KIT and the University of Kiev has now developed a photo-switchable molecule as a basis of an oxygen-independent method.
Photodynamic therapy (PDT) in medicine usually uses a substance that reacts to light and converts the oxygen in the tissue into aggressive radicals. These reactive substances are toxic and damage the neighboring cells, such that e.g. tumors are decomposed...
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