Salk scientists move one step closer to developing ‘exercise-in-a-pill.’ Partial view of a mouse calf muscle stained for different types of muscle fibers: oxidative slow-twitch (blue), oxidative fast-twitch (green), glycolytic fast-twitch (red). Credit: Salk Institute/Waitt Center
For the elderly, obese or otherwise mobility-limited, the rewards of aerobic exercise have long been out of reach. Salk Institute scientists, building on earlier work that identified a gene pathway triggered by running, have discovered how to fully activate that pathway in sedentary mice with a chemical compound, mimicking the beneficial effects of exercise, including increased fat burning and stamina...
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