Immunofluorescence images of spinal cord tissues stained with CD11c-GFP (green), ERβ (red) and nuclear stain DAPI (blue) with merged images for co-localization (yellow) on right. Top row: CD11c-cre-GFP+ control mice showed co-localization (white arrows) of CD11c-GFP and ERβ. Bottom row: CD11c-cre-GFP+;ERβfl/fl CKO mice did not show co-localization (white arrows). Orange arrows represent other cells in the CNS expressing ER&beta. NeuroscienceNews.com image is credited to Kim et al./Brain.
UCLA researchers reveal the mechanism behind how estrogen can protect CNS system damage in people with MS. The researchers report estrogen treatments have positive effects on immune cells in the brain and oligodendrocytes. Complementary actions on these two types provide protection from disease.
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