Nuclear and cytoplasmic PTEN signaling. PTEN localizes to both the cytoplasm and the nucleus and shuttles between each by a variety of mechanisms. PTEN function is, at least in part, determined by its subcellular localization.
Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20-25% of all patients with cancers. Mayo Clinic researchers now have discovered that Pten safeguards against tumor formation by keeping chromosome numbers intact when a cell splits into 2 daughter cells. In this study, the last 3 amino acids of the Pten protein, which are often missing in human cancers, were found to be critical for forming an intact mitotic spindle, a structure required for accurate chromosome segregation.
Pten is the most prominent human tumor suppress...
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