Highlights • REDD1 deletion enhances glucose uptake and glycolysis in hypoxic TAMs via mTOR • Enhanced glycolysis in REDD1 KO TAMs leads to glucose competition (GC) with tECs • GC by REDD1 KO TAMs stabilizes tumor EC junctions and vessels preventing metastasis • mTOR activation is antitumoral in hypoxic TAMs but protumoral in cancer cells
A team has demonstrated that then metabolism of macrophages can be attuned to prevent the spread of cancer. The key is in making these macrophages more prone to ‘steal’ sugar from the cells forming the tumor’s blood vessels. As a result, these blood vessels will be structured more tightly, which can prevent cancer cells from spreading to other organs...
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