repair DNA tagged posts

Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging

Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging
This image is an artistic representation of how APOE2 promotes resilience to cellular senescence maintaining the integrity of DNA and the nuclear envelope. We show a neuron protected by APOE2 represented as orange dots across the cell, with a blue mesh representing the resistance to senescence. We highlight in golden the integrity of the nucleus and the protected genome. Credit: Ella Maru for the Buck Institute

People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer’s disease, but scientists have struggled to explain why...

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New Gene Identified as Cause, Early Indicator of Breast Cancer

Dr. Nahid Mivechi, cell biologist and radiobiologist, a group leader at the Cancer Center and a study co-author; Dr. Nita Maihle, MCG cancer biologist, associate center director for education at the university's Cancer Center and a study co-author; Dr. Lan Ko, cancer biologist in the Department of Pathology at the Medical College of Georgia at Augusta University and at the Georgia Cancer Center at AU Credit: Phil Jones

Dr. Nahid Mivechi, cell biologist and radiobiologist, a group leader at the Cancer Center and a study co-author; Dr. Nita Maihle, MCG cancer biologist, associate center director for education at the university’s Cancer Center and a study co-author; Dr. Lan Ko, cancer biologist in the Department of Pathology at the Medical College of Georgia at Augusta University and at the Georgia Cancer Center at AU Credit: Phil Jones

When mutated, a gene known for its ability to repair DNA, appears to instead cause breast cancer. The gene GT198, whether mutated by genetics and/or environmental factors, has strong potential as both as a way to diagnose breast cancer early and as a new treatment target, said Dr. Lan Ko...

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