A metal-free ribonucleotide reductase–an enzyme required for DNA replication–from bacterial pathogens uses a post-translationally modified amino acid (pictured) to initiate an essential DNA biosynthesis reaction. The modification (indicated by arrow) is essential for initiation of ribonucleotide reduction. This metal-free enzyme could allow microbes associated with strep throat and pneumonia infections to more effectively proliferate during iron/manganese limitation imposed by the human immune system.
Credit: Gavin Palowitch, Penn State
A new study shows that some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA using a ribonucleotide reductase enzyme that does not require a metal ion cofactor...
Read More
Recent Comments