RIPK1 tagged posts

An international research team has discovered a previously unknown mechanism that plays a key role in the signaling pathways involved in programmed cell death. The team identified the protein HERC4 as an essential component of both TNF-induced necroptosis and apoptosis pathways—two processes that play a crucial role in maintaining cellular balance and triggering inflammatory responses.

The study, “HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death,” was published in Nature Structural and Molecular Biology. The lead researchers were Dr...

A soft, gel-like substance called myelin envelopes the axons of neurons to shield them from damage. In ALS, the protective sheath is gradually stripped off, leaving axons bare, exposed and vulnerable to damage. Harvard Medical School researchers have identified a key instigator of this process.

Scientists have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, or ALS. Researchers say the findings of their study may lead to new therapies to halt the progression of the uniformly fatal disease that affects more than 30,000 Americans. One such treatment is already under development for testing in humans after the current study showed it stopped nerve cell damage in mice with ALS.

The HMS study reveals that the aberrant behavior of an enzyme called RI...