Schematic model of PUM2 impact on age-related mitochondrial function. PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in Ribonucleoprotein particles (RNP). Consequently, PUM2 prevents Mff translation, impairing mitochondrial fission and mitophagy thereby leading to mitochondrial dysfunction. Credit: Davide D’Amico
Researchers have found that the RNA-binding protein PUM2 contributes to the accumulation of defective mitochondria, a key feature of the aging process. Targeting PUM2 in old animals protects against age-related mitochondrial dysfunction...
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