SARS-CoV-2 tagged posts

Handheld Device Offers Lab-Quality Diagnostic Testing

Handheld device offers lab-quality diagnostic testing

The LIAMT handheld processor features a window which the user can look through to view fluorescent virus detection signals. Credit: Advanced Science (2024). DOI: 10.1002/advs.202310066

Because of its high accuracy, laboratory-based polymerase chain reaction (PCR) testing is the gold standard for infectious disease diagnostics. However, PCR technology requires highly trained staff and costly equipment, hindering its availability, especially in low-resource settings. New research suggests a different kind of test could be more streamlined without sacrificing performance.

A platform technology developed by researchers at the University of Connecticut uses similar techniques as PCR testing, but within a handheld device rather than several benchtop machines.

In a study publish...

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COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

COVID-19 research: New details about potentially deadly inflammation revealed in USC study
SARS-CoV-2 NSP14 facilitates the activation of NF-κB signaling and inflammatory response. a, HEK293T cells were transfected with the plasmids of 27 SARS-CoV-2 proteins, along with MyD88 and a reporter plasmid carrying the NF-κB promoter (NF-κB-Luc) and the cells were analyzed for NF-κB activity by reporter gene assay. The horizontal dashed line indicates the activation level of the positive control (EV+MyD88) group. b, Expression of the proinflammatory genes TNFA, IL1B, IL6 and IL8 in human MDMs transfected with NSP14-specific or scramble control (Ctrl) siRNA, followed with SARS-CoV-2 infection at MOI = 1 for 48 h. c, Expression of the proinflammatory genes from b in Dox-inducible SARS-CoV-2 NSP14-expressing THP-1 cells, measured after treatment with Dox (1 μg ml...
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Severe Lung Infection during COVID-19 can cause Damage to the Heart

Vector illustration of a heart and coronavirus

SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a study has found. The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV-2-associated acute respiratory distress syndrome (ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.

Scientists have long known that COVID-19 increases the risk of heart attack, stroke, and Long COVID, and prior imaging research has shown that over 50% of people who get COVID-19 experience some inflammation or damage to the heart...

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Long-term Analysis reveals SARS-CoV-2 Infection and Vaccine-induced Antibody Responses are Long-Lasting

research

A long-term analysis conducted by leading microbiologists at the Icahn School of Medicine at Mount Sinai reveals that antibody responses induced by COVID-19 vaccines are long-lasting. The study results, published online in the journal Immunity challenge the idea that mRNA-based vaccine immunity wanes quickly.

The emergence of SARS-CoV-2, the virus that causes COVID-19, in late 2019 sparked the global pandemic that is now in its fifth year. Vaccines that were developed at record speed have saved millions of lives. However, the emergence of SARS-CoV-2 variants and waning immunity have decreased the effectiveness of the vaccines against symptomatic disease. The common perception now is that mRNA-based vaccine-induced immunity wanes quickly.

However, this assumption is largely based...

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