SARS-CoV-2 tagged posts

COVID-19 linked to increase in biomarkers for abnormal brain proteins

COVID-19 linked to increase in biomarkers for abnormal brain proteins
Study overview. Credit: Nature Medicine (2025). DOI: 10.1038/s41591-024-03426-4

Researchers have uncovered a link between COVID-19 and blood markers linked to faulty proteins in the brain. The analysis, led by researchers at Imperial College London and the UK Dementia Research Institute, found that people who had previously had COVID-19 were more likely to have increased levels of biomarkers linked to faulty amyloid proteins—a known hallmark for Alzheimer’s disease.

On average, the effects were comparable to four years of aging with the greatest effects seen in those hospitalized with severe COVID-19 or with underlying risk factors for dementia such as smoking or high blood pressure.

According to the researchers, the findings suggest that mild or moderate COVID-19 may acceler...

Read More

Handheld Device Offers Lab-Quality Diagnostic Testing

Handheld device offers lab-quality diagnostic testing

The LIAMT handheld processor features a window which the user can look through to view fluorescent virus detection signals. Credit: Advanced Science (2024). DOI: 10.1002/advs.202310066

Because of its high accuracy, laboratory-based polymerase chain reaction (PCR) testing is the gold standard for infectious disease diagnostics. However, PCR technology requires highly trained staff and costly equipment, hindering its availability, especially in low-resource settings. New research suggests a different kind of test could be more streamlined without sacrificing performance.

A platform technology developed by researchers at the University of Connecticut uses similar techniques as PCR testing, but within a handheld device rather than several benchtop machines.

In a study publish...

Read More

COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

COVID-19 research: New details about potentially deadly inflammation revealed in USC study
SARS-CoV-2 NSP14 facilitates the activation of NF-κB signaling and inflammatory response. a, HEK293T cells were transfected with the plasmids of 27 SARS-CoV-2 proteins, along with MyD88 and a reporter plasmid carrying the NF-κB promoter (NF-κB-Luc) and the cells were analyzed for NF-κB activity by reporter gene assay. The horizontal dashed line indicates the activation level of the positive control (EV+MyD88) group. b, Expression of the proinflammatory genes TNFAIL1BIL6 and IL8 in human MDMs transfected with NSP14-specific or scramble control (Ctrl) siRNA, followed with SARS-CoV-2 infection at MOI = 1 for 48 h. c, Expression of the proinflammatory genes from b in Dox-inducible SARS-CoV-2 NSP14-expressing THP-1 cells, measured after treatment with Dox (1 μg ml...
Read More

Severe Lung Infection during COVID-19 can cause Damage to the Heart

Vector illustration of a heart and coronavirus

SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a study has found. The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV-2-associated acute respiratory distress syndrome (ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.

Scientists have long known that COVID-19 increases the risk of heart attack, stroke, and Long COVID, and prior imaging research has shown that over 50% of people who get COVID-19 experience some inflammation or damage to the heart...

Read More