SARS-CoV-2 tagged posts

COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

COVID-19 research: New details about potentially deadly inflammation revealed in USC study
SARS-CoV-2 NSP14 facilitates the activation of NF-κB signaling and inflammatory response. a, HEK293T cells were transfected with the plasmids of 27 SARS-CoV-2 proteins, along with MyD88 and a reporter plasmid carrying the NF-κB promoter (NF-κB-Luc) and the cells were analyzed for NF-κB activity by reporter gene assay. The horizontal dashed line indicates the activation level of the positive control (EV+MyD88) group. b, Expression of the proinflammatory genes TNFA, IL1B, IL6 and IL8 in human MDMs transfected with NSP14-specific or scramble control (Ctrl) siRNA, followed with SARS-CoV-2 infection at MOI = 1 for 48 h. c, Expression of the proinflammatory genes from b in Dox-inducible SARS-CoV-2 NSP14-expressing THP-1 cells, measured after treatment with Dox (1 μg ml...
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Severe Lung Infection during COVID-19 can cause Damage to the Heart

Vector illustration of a heart and coronavirus

SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a study has found. The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV-2-associated acute respiratory distress syndrome (ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.

Scientists have long known that COVID-19 increases the risk of heart attack, stroke, and Long COVID, and prior imaging research has shown that over 50% of people who get COVID-19 experience some inflammation or damage to the heart...

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Long-term Analysis reveals SARS-CoV-2 Infection and Vaccine-induced Antibody Responses are Long-Lasting

research

A long-term analysis conducted by leading microbiologists at the Icahn School of Medicine at Mount Sinai reveals that antibody responses induced by COVID-19 vaccines are long-lasting. The study results, published online in the journal Immunity challenge the idea that mRNA-based vaccine immunity wanes quickly.

The emergence of SARS-CoV-2, the virus that causes COVID-19, in late 2019 sparked the global pandemic that is now in its fifth year. Vaccines that were developed at record speed have saved millions of lives. However, the emergence of SARS-CoV-2 variants and waning immunity have decreased the effectiveness of the vaccines against symptomatic disease. The common perception now is that mRNA-based vaccine-induced immunity wanes quickly.

However, this assumption is largely based...

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New Vaccine design uses Immunity against Influenza to offer Faster Protection against Emerging Pathogens

After COVID vaccination, it usually takes weeks for our bodies to develop protective antibody responses. Imagine, however, a vaccine that speeds up the production of antibodies against SARS-CoV-2, the virus that spreads COVID-19.

A research team led by Rong Hai, an associate professor of microbiology and plant pathology at the University of California, Riverside, has developed such a vaccine by using preexisting immunity to a separate virus (the influenza virus) to help kickstart the process of making antibodies against SARS-CoV-2.

“Any delay in the immune response to SARS-CoV-2 means there is some time when people are left poorly protected against the virus,” Hai said...

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