Cellular senescence in human cells. Credit: Eva Latorre
Breakthrough could be ‘basis for a new generation of anti-degeneration drugs’. Key aspects of the ageing of human cells can be reversed by new compounds developed at the University of Exeter, research shows. In a laboratory study of endothelial cells – which line the inside of blood vessels – researchers tested compounds designed to target mitochondria.
In the samples used in the study, the number of senescent cells (older cells that have deteriorated and stopped dividing) was reduced by up to 50%. The Exeter team also identified 2 splicing factors (a component of cells) that play a key role in when and how endothelial cells become senescent.
The findings raise the possibility of future treatments not only for blood vessels – which be...
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