Adult C. elegans worms can be seen with embryos inside them. Credit: Adam Klosin, CRG.
Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to 5 generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes. Their results, which will be published in Science Advances on 16 August, will change the way we think about the impact of replication stress in cancer and during embryonic development, as well as its inter-generational inheritance.
There are two particular processes in which cell division is crucial: embryonic development and tumorigenesis...
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