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    Small molecules fighting Aging-related Diseases

    March 8, 2017, Categories  Health/Medical, Biology/Biotechnology

    One of the activating molecules synthesized by the research group binds to Sirtuin 6. The chemical name of the activator is “4-(pyridine-3-yl)-4,5-dihydropyrrolo[1,2-α]quinoxaline”. Illustration: Clemens Steegborn (free with attribution).

    One of the activating molecules synthesized by the research group binds to Sirtuin 6. The chemical name of the activator is “4-(pyridine-3-yl)-4,5-dihydropyrrolo[1,2-α]quinoxaline”. Illustration: Clemens Steegborn (free with attribution).

    For the first time molecules able to activate enzyme sirtuin 6 has been produced by an international research network led by Bayreuth Biochemist Prof. Dr. Clemens Steegborn. Furthermore, the scientists were able to reveal the structural basis of such processes. These findings will enable the development of drugs that might support the fight against aging-related diseases. Sirtuins are enzymes that fulfil a variety of regulatory functions in the body. In particular, they regulate energy metabolism and stress responses...

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