skeletal muscle loses its ability to heal after injury tagged posts

In young muscle, high levels of Klotho maintain mitochondia, which aids regeneration after injury. Age-related declines of Klotho lead to mitochondrial damage and impaired healing.
CREDIT
Sahu et al. (2018), Nature Communications

One of the downsides to getting older is that skeletal muscle loses its ability to heal after injury. New research from the University of Pittsburgh implicates the so-called “longevity protein” Klotho, both as culprit and therapeutic target.

The paper, published this week in Nature Communications, showed that, in young animals, Klotho expression soars after a muscle injury, whereas in old animals, it remains flat...