small molecule RNA inhibitors tagged posts

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

TSRI Scientists have designed 2 new drug candidates to target prostate and triple negative breast cancers. The new research, published recently as 2 separate studies in ACS Central Science and Journal of the American Chemical Society, demonstrates that a new class of drugs, small molecule RNA inhibitors can target and kill specific types of cancer. RNA defects can lead to cancers, ALS, myotonic dystrophy and many other diseases. In their ACS Central Science study, Prof. Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates...