Self-assembly of a redox-responsive stomatocyte nanomotor system, which can be used for triggered drug release under biological reducing conditions
Self-destroyed redox-sensitive stomatocyte nanomotor delivers and releases drugs for cells. Autonomous targeting and release of drugs at their site of action are desired features of nanomedical systems. Now, a team of Dutch scientists has designed a nanomotor that has these functions: An antitumor drug encapsulated in self-propelled, self-assembled stomatocytes is carried across the cellular membrane and released inside the cell upon a chemical signal that disassembles the vesicle membrane. This deliver and unpack nanomedicinal system is introduced in the journal Angewandte Chemie.
Self-propelling nanovesicles if fueled by hydrogen peroxide, th...
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