swap of A●T to G●C tagged posts

A newly created DNA base editor contains an atom-rearranging enzyme (red) that can change adenine into inosine (read and copied as guanine), guide RNA (green) which directs the molecule to the right spot, and Cas9 nickase (blue), which snips the opposing strand of DNA and tricks the cell into swapping the complementary base. Credit: Gaudelli et al./ Nature 2017

Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A●T to a G●C. The new enzyme, known as a base editor, may one day enable genome surgery that erases harmful mutations and writes in helpful ones, Howard Hughes Medical Institute (HHMI) Investigator David Liu and colleagues report October 25, 2017, in Nature.

Some genome editing tools eg CRISPR/Cas9, cut...