Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators. The findings are poised to redirect lupus research and open the door to more precise therapies that avoid broad immune suppression.
Published in Nature Immunology, the study used single-cell RNA sequencing to profile CD4⁺ T-cell subtypes from children with SLE and healthy controls...
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