Adsorption may be rate-limiting for the release of positively charged proteins from PLGA np. (i) Initially, the protein is fully adsorbed to the negatively charged nanoparticle surface. (ii) As the nanoparticle begins to degrade, acidic components build up and decrease the local pH. (iii) At a certain threshold, the nanoparticle surface becomes neutral, weakening the electrostatic interactions with the positively charged proteins and initiating release.
It’s a potential game-changer for Rx of chronic illnesses or injuries that often require multiple injections or daily pills. For decades, biomedical engineers have been painstakingly encapsulating proteins in nanoparticles to control their release...
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